The anticipation for the 2025 MLB season is at an all-time high. Fans are eager to see their favorite teams and players hit the diamond.
The Los Angeles Dodgers, last year’s champions, will kick off the season against the Chicago Cubs in Tokyo. With the reigning champions, the Los Angeles Dodgers, set to kick off the season against the Chicago Cubs in Tokyo, the excitement is palpable.
As the season approaches, expert analysts from ESPN have provided a comprehensive betting guide. This blog post will delve into some of the most intriguing bets and insights from the guide, giving you a well-rounded view of what to expect this season.
American League East
Yankees’ Playoff Prospects
The New York Yankees, despite their strong performance last year, face a challenging season ahead. They lost key player Juan Soto and are relying on several aging veterans. With four legitimate playoff contenders in their division, the odds of them missing the playoffs are significant. Betting on the Yankees to miss the playoffs at +280 offers value if you can handle the risk.
Gunnar Henderson for AL MVP
Gunnar Henderson of the Baltimore Orioles is a strong contender for the American League MVP, with odds at +750. His elite quality of contact, sprint speed, and solid defense make him a valuable player. If the Orioles can win the AL East, Henderson’s chances of securing the MVP title are high.
Jarren Duran’s Stolen Bases
Jarren Duran of the Boston Red Sox is projected to steal 40 or more bases this season, with odds at +300. The Red Sox’s aggressive base-running strategy, combined with Duran’s speed, makes this a promising bet.
Junior Caminero’s Home Run Potential
Junior Caminero of the Tampa Bay Rays is expected to hit 30 or more home runs this season, with odds at +225. The move to a more hitter-friendly stadium and his top-shelf power make this a valuable bet.
Vladimir Guerrero Jr. for Hits Leader
Vladimir Guerrero Jr. of the Toronto Blue Jays is a strong candidate to lead the regular season in hits, with odds at +1600. His consistent performance and the prospect of a monster free-agent contract make this a bet worth considering.
American League Central
Carlos Santana’s Home Run Decline
Carlos Santana of the Cleveland Guardians is projected to hit under 19.5 home runs this season, with odds at +100. His age and average power metrics suggest a decline in home run production.
Bobby Witt Jr. for Stolen Bases Leader
Bobby Witt Jr. of the Kansas City Royals is a top contender to lead MLB in stolen bases, with odds at +1600. His elite sprint speed and improved hitting make him a strong candidate.
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Kerry Carpenter’s Home Run Surge
Kerry Carpenter of the Detroit Tigers is expected to hit over 20.5 home runs this season, with odds at -115. His impressive power metrics and performance against right-handed pitching make this a promising bet.
Pablo Lopez for AL Cy Young
Pablo Lopez of the Minnesota Twins is a potential candidate for the American League Cy Young Award, with odds at +1800. His durability and consistent performance make him a strong contender.
Noah Schultz for AL Rookie of the Year
Noah Schultz of the Chicago White Sox is a dark horse candidate for the American League Rookie of the Year, with odds at +6000. His potential and opportunity to make an impact in the rotation make this a high-reward bet.
American League West
Yordan Alvarez’s Home Run Potential
Yordan Alvarez of the Houston Astros is projected to hit over 34.5 home runs this season, with odds at -115. His raw power metrics and the team’s plan to give him more days at DH make this a valuable bet.
Cal Raleigh for AL MVP
Cal Raleigh of the Seattle Mariners is a long shot for the American League MVP, with odds at +7500. His elite defense and potential for improved batting make him an intriguing candidate.
Jacob deGrom’s Strikeout Potential
Jacob deGrom of the Texas Rangers is a strong candidate to lead the regular season in strikeouts, with odds at +3000. His high strikeout rate and potential for a healthy season make this a high-value bet.
Brent Rooker for Home Run Leader
Brent Rooker of the Oakland Athletics is projected to lead the regular season in home runs, with odds at +2500. His impressive power metrics and move to a more hitter-friendly stadium make this a promising bet.
National League East
Francisco Lindor for NL MVP
Francisco Lindor of the New York Mets is a strong contender for the National League MVP, with odds at +2000. His consistent performance and potential for sentimental MVP votes make this a valuable bet.
CJ Abrams’ Stolen Bases
CJ Abrams of the Washington Nationals is projected to steal 40 or more bases this season, with odds at +150. His speed and determination to prove himself make this a promising bet.
Sandy Alcantara for NL Cy Young
Sandy Alcantara of the Miami Marlins is a potential candidate for the National League Cy Young Award, with odds at +2500. His impressive past performance and potential for a strong comeback make this a high-reward bet.
Brice Turang’s Stolen Bases
Brice Turang of the Milwaukee Brewers is expected to steal 40 or more bases this season, with odds at +110. His speed and opportunity to lead off make this a valuable bet.
National League Central
Sonny Gray for NL Cy Young
Sonny Gray of the St. Louis Cardinals is a long shot for the National League Cy Young Award, with odds at +3500. His consistent performance and potential for a trade to a contender make this an intriguing bet.
Matt Shaw for NL Rookie of the Year
Matt Shaw of the Chicago Cubs is a strong candidate for the National League Rookie of the Year, with odds at +450. His power, speed, and plate discipline make him a valuable player to watch.
Elly De La Cruz for NL MVP
Elly De La Cruz of the Cincinnati Reds is a potential candidate for the National League MVP, with odds at +1800. His raw talent and potential for improved contact make this a high-reward bet.
Oneil Cruz’s Home Run Potential
Oneil Cruz of the Pittsburgh Pirates is projected to hit over 23.5 home runs this season, with odds at -115. His impressive power metrics and potential for better luck make this a valuable bet.
National League West
Mookie Betts for NL MVP
Mookie Betts of the Los Angeles Dodgers is a strong contender for the National League MVP, with odds at +1200. His consistent performance and potential for a standout season make this a valuable bet.
Dylan Cease’s Strikeout Potential
Dylan Cease of the San Francisco Giants is a strong candidate to lead the regular season in strikeouts, with odds at +1600. His elite “swing-and-miss” stuff and consistent performance make this a high-value bet.
Diamondbacks to Win NL West
The Arizona Diamondbacks are a dark horse candidate to win the National League West, with odds at +1000. Their well-rounded roster and potential for a strong season make this an intriguing bet.
Logan Webb for Wins Leader
Logan Webb of the San Francisco Giants is a strong candidate to lead the regular season in wins, with odds at +2500.
His durability and ability to go deep into games make this a valuable bet.
For more detailed insights and the latest odds on these and other bets, visit the 2025 ESPN Bet MLB Betting Guide.

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