Top MLB Series This Week: Postseason-Level Pitching Matchups

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As the 2025 Major League Baseball season begins, fans are witnessing the intensity and excitement that will shape the race to October. Early-season matchups often provide a glimpse into potential postseason scenarios, and this week is no exception.

From pitching duels to budding rivalries, here are five series that promise to captivate baseball enthusiasts. For a detailed breakdown of these matchups, you can check out the full article on MLBโ€™s website.

Orioles at Diamondbacks (Monday-Wednesday)

The Baltimore Orioles and Arizona Diamondbacks will face off in their first and only series of the season. Last year, the Orioles took two out of three games in Baltimore, but the Diamondbacks outscored them 15-12.

This series is particularly intriguing as both teams aim to assert themselves as serious contenders.

Key Storyline

After a strong showing at Yankee Stadium last week, the Diamondbacks have another opportunity to make a statement against an American League World Series hopeful.

With the Dodgers, Padres, and Giants starting hot in the National League West, and the Yankees dominating AL headlines, both the Orioles and Diamondbacks are eager to prove they belong in the conversation.

Pitching Matchup to Watch

Although Arizonaโ€™s Corbin Burnes wonโ€™t be pitching against his former team, the series opener features a compelling duel between Opening Day starters Zac Gallen and Zach Eflin.

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Gallen, who recently struck out 13 Yankees, has allowed seven runs in 11 1/3 career innings against Baltimore. Meanwhile, Eflin boasts a 3.18 ERA in five appearances against Arizona.

Yankees at Tigers (Monday-Wednesday)

The New York Yankees and Detroit Tigers meet for the first time in 2025, following a season where the Yankees won four of six games. The Tigers, however, had a late-season surge, finishing 33-17 over their final 50 games to clinch a playoff spot.

Both teams are looking to build on their past performances and set the tone for the season.

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Key Storyline

The Tigers aim to prove that their late-season momentum from 2024 was no fluke, while the Yankees seek to reestablish their dominance over another playoff hopeful.

This series marks the Yankeesโ€™ first against an AL opponent in 2025, adding an extra layer of intrigue.

Pitching Matchup to Watch

Expect stellar pitching throughout the series, starting with a Monday showdown between Carlos Rodon and Casey Mize.

On Tuesday, reigning Cy Young winner Tarik Skubal takes the mound for Detroit, followed by a Wednesday clash featuring Jack Flaherty and Max Fried. Skubalโ€™s 12-strikeout performance against the Yankees last May is still fresh in fansโ€™ minds.

Phillies at Braves (Tuesday-Thursday)

In the first of 13 meetings this season, the Philadelphia Phillies and Atlanta Braves renew their NL East rivalry. Last year, Atlanta won the season series 7-6, but Philadelphia took three of the final four games. Historically, the Braves lead the all-time series 1,325-1,204.

Key Storyline

With the Braves off to a 1-8 start, questions arise about the future of this once-dominant rivalry.

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However, the return of catcher Sean Murphy from the Injured List and the impending return of star pitcher Spencer Strider could provide the boost Atlanta needs.

Pitching Matchup to Watch

The highlight of this series is Tuesdayโ€™s pitching duel between Zack Wheeler and Chris Sale.

Sale, who won his first Cy Young Award last year, faces a formidable opponent in Wheeler, who has a 2.95 ERA in 30 starts against the Braves. Sale hasnโ€™t faced the Phillies since March 2024, making this a highly anticipated matchup.

Rangers at Mariners (Friday-Sunday)

The Texas Rangers and Seattle Mariners square off for the first time in 2025. Last season, Seattle dominated the series, winning 10 of 13 games, with five of those victories decided by just one run.

This series could be pivotal for both teams as they seek to establish themselves in the AL West.

Key Storyline

The Mariners are struggling to find their offensive rhythm, averaging just over three runs per game with a team batting average hovering around .200.

Rediscovering their offense is crucial if they hope to compete in a tough division.

Pitching Matchup to Watch

Fridayโ€™s game features Jacob deGrom for Texas against Seattleโ€™s Bryce Miller, who posted a 2.94 ERA in 31 starts last year.

The series continues with rookie Kumar Rocker pitching for Texas on Saturday against Bryan Woo, followed by a Sunday showdown between Nathan Eovaldi and Logan Gilbert.

Cubs at Dodgers (Friday-Sunday)

The Chicago Cubs and Los Angeles Dodgers clash for the second time this season, following their Opening Day series in Tokyo, where the Dodgers won both games. The Cubs rebounded to win seven of their next nine games, taking first place in the NL Central, while the Dodgers started the season 8-0.

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Key Storyline

Both teams made significant offseason acquisitions that are already paying dividends.

The Cubsโ€™ Kyle Tucker, acquired from Houston, has five home runs and a 1.203 OPS, while left-hander Matthew Boyd hasnโ€™t allowed a run in his first two starts. For the Dodgers, new outfielder Michael Conforto boasts a 1.021 OPS.

Pitching Matchup to Watch

Fridayโ€™s game features a fascinating duel between Matthew Boyd and Dodgers rookie Roki Sasaki.

Boydโ€™s early-season dominance and Sasakiโ€™s potential make this a must-watch game.

As these early-season series unfold, fans will get a clearer picture of which teams are poised for postseason success.

For more detailed insights into these matchups, visit the full article on MLBโ€™s website.

Joe Hughes
Joe Hughes is the founder of CollegeNetWorth.com, a comprehensive resource on college athletes' earnings potential in the NIL era. Combining his passion for sports with expertise in collegiate athletics, Joe provides valuable insights for athletes, fans, and institutions navigating this new landscape.

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